All Technologies
• High-Throughput Protein Crystal Screening and Structure Analysis Technology
High-Throughput Protein Crystal Screening and Structure Analysis Technology X-ray crystallography is an important tool for understanding not only the chemical properties of crystals but also the three-dimensional molecule structures. It is one of the most common techniques used by structural biologists. The Protein Data Bank (PDB) currently has over 170,000 structures of biomacromolecules, and X-ray crystallography has played an important role in this field, providing atomic coordinates for about
• Cryo-EM Single Particle Analysis Technology
Cryo-EM Single Particle Analysis Technology Cryo-Electron Microscopy (Cryo-EM) is an ultra-low temperature frozen sample preparation and transfer technology based on electron microscopy, which can directly observe liquid, semi-liquid, and beam-sensitive samples, such as biological samples and polymer materials, etc. Since winning the Nobel Prize in Chemistry in 2017, Cryo-EM technology has become one of the most advanced and promising techniques in the field of biomedicine, especially in preclini
• Micro-Crystal Electron Diffraction
Micro-Crystal Electron Diffraction In the field of structural biology, Micro-crystal Electron Diffraction (MicroED) and Single Particle Analysis (SPA) are two pivotal research methodologies based on Cryo-Electron Microscopy (Cryo-EM). SPA is particularly adept at resolving the 3D structures of soluble proteins, membrane proteins, and large protein complexes in conditions that are close to their natural, fully hydrated state. The difference is, MicroED is capable of rapidly determining the crystal
• Reduced Graphene Oxide Support Film
Reduced Graphene Oxide Support Film Graphene has become the first two-dimensional material that can exist stably in nature since Novoselov et al. successfully separated it from graphite by mechanical stripping in 2004. According to the defects and groups generated on the surface of graphene during the preparation process, graphene can be functionalized and modified to change certain properties and obtain graphene derivatives. Functionalized graphene and its derivatives have better water solubilit
• Structure-Based Drug Discovery Technology
Structure-Based Drug Discovery Technology The discovery of lead compounds is an upstream process of drug development, in which computer-aided virtual screening plays a crucial role. From the perspective of drug design, virtual screening has two strategies: ligand-based and structure-based. The two approaches are specific to different use cases and complement each other. In the context of known receptor structures, structure-based virtual screening has demonstrated its utility and reliability, so
• Lipid Nanodiscs Assembly Technology
Lipid Nanodiscs Assembly Technology Lipid Nanodiscs are disc-like lipid bilayer structures with a diameter of 8-16 nm, stabilized by two encircling amphiphilic helical proteins, known as membrane scaffold proteins, or MSPs, to make them soluble in water. MSPs can be seen as scaled-down versions of Apolipoprotein A-I, which surrounds the lipid bilayer to form a membrane-like disc structure. The hydrophobic residues of MSPs are located internally and can interact with the hydrophobic tails of phosp